Human Liver Microsomes: Structure & Function
Illustration of Human liver microsomes as small membrane-bound vesicles formed from the endoplasmic reticulum (ER) of liver cells during cell fractionation. They retain several important enzymes involved in drug metabolism, particularly cytochrome P450 enzymes, along with other membrane-associated proteins. This makes them useful for studying how compounds are metabolized in the liver. The figure illustrates where microsomes originate within the hepatocyte, their basic structure, and how their enzyme systems contribute to the metabolism of drugs and other compounds.
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